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#Hrd score professional

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of American Society for Clinical Pathology (ASCP) and Association for Molecular Pathology (AMP). To earn CME/CMLE credit, all learners must watch the webinar and then complete the online survey. Last Day to Claim CE Credit: December 31, 2022 This program has been supported through an educational grant from Bristol-Myers Squibb. Apply HRD score information so as to order appropriate testing and interpret test results within a clinical context. Outline the strengths and limitations of described testing approaches.4. Discuss the appropriate technical approaches and platforms for HRD score molecular diagnostic testing.ģ. Describe the biological principles that underlie the relevance of HRD score, including the cellular signaling pathways and cellular processes involved.Ģ. The scientific background, testing considerations, and clinical implications will be discussed in this presentation.ġ. HRD score has been studied in multiple tumor types with the aim of predicting therapeutic response independent of homologous recombination repair gene mutation status.

#Hrd score professional

This assay is for professional use only and is to be performed only at Myriad Genetic Laboratories, Inc., a single laboratory site located at 320 Wakara Way, Salt Lake City, UT 84108.This webinar is a recorded presentation of a live broadcast and includes the presentation, handout, and the audience QA.ĭescription:Homologous recombination deficiency score (HRD) includes assessment of loss of heterozygosity, large-scale state transitions, and telomeric allelic imbalance as an assessment of functional loss of homologous recombination repair. * Refer to the drug label for HRD definition for olaparib monotherapy or combination therapyĭetection of deleterious or suspected deleterious BRCA1 and BRCA2 mutations and/or positive Genomic Instability Score in ovarian cancer patients is also associated with enhanced progression-free survival (PFS) from Zejula ® (niraparib) maintenance therapy.

deleterious or suspected deleterious mutations in BRCA1and BRCA2 genes and/or.

Table 1: Companion diagnostic indications Tumor Type The results of the test are used as an aid in identifying ovarian cancer patients with positive homologous recombination deficiency (HRD) status, who are eligible, because of a positive test result for deleterious or suspected deleterious mutations in BRCA1 or BRCA2 genes, or may become eligible, because of a positive test result for deleterious or suspected deleterious mutations in BRCA1 or BRCA2 genes or a positive Genomic Instability Score, for treatment with the targeted therapy listed in Table 1 in accordance with the approved therapeutic product labeling. Myriad m圜hoice ® CDx is a next generation sequencing-based in vitro diagnostic test that assesses the qualitative detection and classification of single nucleotide variants, insertions and deletions, and large rearrangement variants in protein coding regions and intron/exon boundaries of the BRCA1 and BRCA2 genes and the determination of Genomic Instability Score (GIS) which is an algorithmic measurement of Loss of Heterozygosity (LOH), Telomeric Allelic Imbalance (TAI), and Large-scale State Transitions (LST) using DNA isolated from formalin-fixed paraffin embedded (FFPE) tumor tissue specimens.